Struggling to lose weight? Metformin can do more than help control your blood sugar — it may also help you lose stubborn pounds. The relationship between metformin and weight is unclear, but several theories provide possible explanations for weight fluctuations. For example, metformin may affect hunger cues. In one small study, 12 women with obesity and type 2 diabetes who were not taking insulin were randomly given two dose levels of metformin — milligrams mg or 1, mg — or a placebo three times a day for three days, with each participant going through the study three times so they had each dose and the placebo. Participants received a meal test on each third day and rated their hunger level before eating. Researchers found that hunger levels in the metformin group were significantly lower, especially after the participants took the 1, mg dose compared with when they were taking the lower metformin dose or placebo. This subtle change in appetite could be responsible for a gradual decline in weight. Having a frequent upset stomach or diarrhea, which is another side effect of the drug, can also affect your food intake.
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