Services on Demand Journal. The area under the blood glucose curve AUC was calculated using the following [ 17 ]. Fung T. Glendinning J. Furthermore, in this animal model of IR, insulin may not inhibit the de novo glucose production by the liver, leading therefore to elevated gluconeogenesis, resulting in elevated blood glucose levels in the fed state, as previously reported [ 35 ], as well as altered glucose tolerance during a GTT. Biochem Biophys Res Commun. In fact, high-sucrose diets may increase adiposity by stimulating liver lipogenesis [ 22 ].
Journal of Zhejiang University. B, 01 Jul , 19 7 : DOI: Free to read. Objective: The present study aims at determining the stability of a popular type 2 diabetes rat model induced by a high-fat diet combined with a low-dose streptozotocin injection. Changes in biochemical parameters were monitored during the 4 weeks. Results: All the rats developed more severe dyslipidemia and hepatic dysfunction after streptozotocin injection. Conclusions: This model easily recovers with normal diet feeding. A high-fat diet is suggested as the background diet in future pharmacological studies using this model. Type 2 diabetes mellitus T2DM is an increasingly common disorder characterized by chronic hyperglycemia and marked dyslipidemia Vinson and Zhang, ; Bhattacharya et al. The World Health Organization WHO estimates that the diabetic population will increase to million people by , which is 4.
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