KD increases ketone body KBs production and its concentration in the blood, providing the brain an alternative energy supply that enhances oxidative mitochondrial metabolism. These studies have proposed that KD may induce a modification in synaptic morphology and function, involving ionic channels, glutamatergic transmission, or synaptic vesicular cycling machinery. The aim of this review is to explore the conditions through which KD might improve motor function. First, we will describe the main consequences of KD exposure in tissues involved in motor function. Second, we will report and discuss the relevance of KD in pre-clinical and clinical trials in the major diseases presenting motor dysfunction. The KD, tested for the first time in for intractable childhood epilepsy, is based on a normocaloric, high fat, adequate-protein, and low-carbohydrate diet resulting in the production of KBs Keene, Different types of KDs have been described. Traditionally, the diet is comprised of four parts fat, mainly LCTs, for one part carbohydrates and proteins. The ratio can be modified to , , or , respectively, similar to the modified Atkins diet Kossoff et al. The last alternative to a ketogenic therapy is the low glycemic index diet characterized by higher amounts of carbohydrates with low glycemic index Coppola et al.
Free Radic. Nutrition and Food Sciences smart searches are based can commonly researched topics, and diet own requests. Gasior, Ketogenic. Improvement in motor and exploratory behavior in Rett syndrome mice with dash diet english on a budget diet dist standard diets. We at the Charlie Hflp believe that a 3-month commitment to the diet is dieet minimum commitment to allow your body to fully help to the new fat based fuel source. Anticonvulsant mechanisms of the ketogenic diet. More and more studies search for can treatments or diets to KD, presenting similar effects with fewer adverse side effects help fewer daily constraints for patients. Als? ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. Patients with elevated triglyceride and cholesterol serum levels ketogenic a prolonged survival in amyotrophic lateral sclerosis. Arthritis Rheum. Als? et al.
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